Panathinaikos, along with Aris, are the only Greek teams never to have been relegated from the top division, with participation in every Greek First Division Championship.
Panathinaikos has developed into the most successful basketball club in Greek basketball history and one of the most successful teams in European basketball. The team has won seven EuroLeague Championships, forty Greek Basket League Championships, twenty-two Greek Cups, one Intercontinental Cup, one Greek Super Cup, and two Triple Crowns. The Greens count one more Greek Championship (forty-one in total), that took place in 1921 and was organized by the YMCA, but is not officially recognized, because it was before the creation of the Hellenic Basketball Association. They hold the world record for the longest title-winning streak, spanning 27 seasons from 1995–96 to 2021–22, during which the team won at least one title each season.